Oxidative Amide Synthesis and N-Terminal α-Amino Group Ligation of Peptides in Aqueous Medium
- 27 October 2006
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (46), 14796-14797
- https://doi.org/10.1021/ja064479s
Abstract
A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.This publication has 36 references indexed in Scilit:
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