Outbreaks of Hydropericardium Syndrome and Molecular Characterization of Korean Fowl Adenoviral Isolates
- 1 September 2008
- journal article
- research article
- Published by American Association of Avian Pathologists (AAAP) in Avian Diseases
- Vol. 52 (3), 526-530
- https://doi.org/10.1637/8178-112207-case
Abstract
Outbreaks ofhydropericardium syndrome (HPS), caused by fowl adenovirus serotype 4 (FAdV-4), have occurred in Korea and caused severe economic loss due to mortality and weight loss. From these outbreaks, several adenoviruses were isolated and identified in samples from broilers, layers, breeders, and native Korean fowl. In pathologic examinations, hydropericardium and multifocal hepatic necrosis, with an intranuclear inclusion body in hepatocytes, were observed. Specific adenovirus particles were also observed in the nucleus of hepatocytes, by electron microscopic examination. Polymerase chain reaction (PCR) analysis of the hexon gene identified all of the isolates as FAdV, serotype 4 and genotype C. To reproduce FAdV-4 field cases, 8- and 52-week-old specific pathogen free (SPF) chicks were infected intramuscularly with the field isolate CBU070244. The mortality rate of infected chicks ranged from 10%-40%, and specific pathologic lesions, such as swollen livers and hydropericardium, were observed. Further studies to determine the prevalence of infection, and analysis of the economic impact to the poultry industry, are needed in the near future.Keywords
This publication has 15 references indexed in Scilit:
- Genetic Characterization, Pathogenicity, and Protection Studies with an Avian Adenovirus Isolate Associated with Inclusion Body HepatitisAvian Diseases, 2007
- Phylogenetic analysis of fowl adenovirusesAvian Pathology, 2004
- Polymerase chain reaction combined with restriction enzyme analysis for detection and differentiation of fowl adenovirusesAvian Pathology, 2001
- Epidemiological studies on fowl adenoviruses isolated from cases of infectious hydropericardiumAvian Pathology, 1999
- Histology, immunohistochemistry, and ultrastructure of hydropericardium syndrome in adult broiler breeders and broiler chicks.Avian Diseases, 1998
- Some strains of serotype 4 fowl adenoviruses cause inclusion body hepatitis and hydropericardium syndrome in chickensAvian Pathology, 1998
- Hydropericardium syndrome in broiler chickens: its contagious nature and pathologyResearch in Veterinary Science, 1995
- Inclusion body hepatitis–anaemia and hydropericardium syndromes: aetiology and controlWorld's Poultry Science Journal, 1992
- New syndrome in Iraqi chicksPublished by Wiley ,1991
- An adenovirus infection of poultry in Pakistan.Revue Scientifique et Technique de l'OIE, 1989