Integron Involvement in Environmental Spread of Antibiotic Resistance
Open Access
- 1 January 2012
- journal article
- Published by Frontiers Media SA in Frontiers in Microbiology
- Vol. 3, 119
- https://doi.org/10.3389/fmicb.2012.00119
Abstract
The spread of antibiotic-resistant bacteria is a growing problem and a public health issue. In recent decades, various genetic mechanisms involved in the spread of resistance genes among bacteria have been identified. Integrons – genetic elements that acquire, exchange, and express genes embedded within gene cassettes (GC) – are one of these mechanisms. Integrons are widely distributed, especially in Gram-negative bacteria; they are carried by mobile genetic elements, plasmids, and transposons, which promote their spread within bacterial communities. Initially studied mainly in the clinical setting for their involvement in antibiotic resistance, their role in the environment is now an increasing focus of attention. The aim of this review is to provide an in-depth analysis of recent studies of antibiotic-resistance integrons in the environment, highlighting their potential involvement in antibiotic-resistance outside the clinical context. We will focus particularly on the impact of human activities (agriculture, industries, wastewater treatment, etc.).Keywords
This publication has 98 references indexed in Scilit:
- qnrVC-Like Gene Located in a Novel Complex Class 1 Integron Harboring the ISCR1Element in anAeromonas punctataStrain from an Aquatic Environment in Shandong Province, ChinaAntimicrobial Agents and Chemotherapy, 2010
- Novel Insights about Class 2 Integrons from Experimental and Genomic EpidemiologyAntimicrobial Agents and Chemotherapy, 2010
- Worldwide Prevalence of Class 2 Integrases outside the Clinical Setting Is Associated with Human ImpactApplied and Environmental Microbiology, 2009
- The SOS Response Controls Integron RecombinationScience, 2009
- The role of natural environments in the evolution of resistance traits in pathogenic bacteriaProceedings. Biological sciences, 2009
- Prevalence of Sulfonamide Resistance Genes in Bacterial Isolates from Manured Agricultural Soils and Pig Slurry in the United KingdomAntimicrobial Agents and Chemotherapy, 2009
- Recovery of a Functional Class 2 Integron from an Escherichia coli Strain Mediating a Urinary Tract InfectionAntimicrobial Agents and Chemotherapy, 2008
- Antibiotics and Antibiotic Resistance Genes in Natural EnvironmentsScience, 2008
- Enterobacteriaceae Bloodstream Infections: Presence of Integrons, Risk Factors, and OutcomeAntimicrobial Agents and Chemotherapy, 2007
- Sampling the Antibiotic ResistomeScience, 2006