Anorectal malignant melanomas: Retrospective experience with surgical management
Open Access
- 1 January 2011
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 17 (4), 534-9
- https://doi.org/10.3748/wjg.v17.i4.534
Abstract
To present the experience and outcomes of the surgical treatment for the patients with anorectal melanoma from the Cancer Hospital, Chinese Academy of Medical Sciences. Medical records of the diagnosis, surgery, and follow-up of 56 patients with anorectal melanoma who underwent surgery between 1975 and 2008 were retrospectively reviewed. The factors predictive for the survival rate of these patients were identified using multivariate analysis. The 5-year survival rate of the 56 patients with anorectal melanoma was 20%, 36 patients underwent abdominoperineal resection (APR) and 20 patients underwent wide local excision (WLE). The rates of local recurrence of the APR and WLE groups were 16.13% (5/36) and 68.75% (13/20), (P = 0.001), and the median survival time was 22 mo and 21 mo, respectively (P = 0.481). Univariate survival analysis demonstrated that the number of tumor and the depth of invasion had significant effects on the survival (P < 0.05). Multivariate analysis showed that the number of tumor [P = 0.017, 95% confidence interval (CI) = 1.273-11.075] and the depth of invasion (P = 0.015, 95% CI = 1.249-7.591) were independent prognostic factors influencing the survival rate. Complete or R0 resection is the first choice of treatment for anorectal melanoma, prognosis is poor regardless of surgical approach, and early diagnosis is the key to improved survival rate for patients with anorectal melanoma.Keywords
This publication has 22 references indexed in Scilit:
- Effect of misdiagnosis on the prognosis of anorectal malignant melanomaZeitschrift für Krebsforschung und Klinische Onkologie, 2010
- What is the best surgical treatment for anorectal melanoma?International Journal of Colorectal Disease, 2004
- Biochemotherapy in patients with metastatic anorectal mucosal melanomaCancer, 2004
- Anorectal melanoma: surgical management guidelines according to tumour thicknessBritish Journal of Cancer, 2003
- Metastasis genes: A progression puzzleNature, 2002
- Anorectal melanomaDiseases of the Colon & Rectum, 1995
- Patterns of Failure in Anorectal MelanomaArchives of Surgery, 1990
- Anorectal melanomaCancer, 1981
- Malignant melanoma of the anorectumDiseases of the Colon & Rectum, 1980
- A comparative study of melanoma and epidermoid carcinoma of the anal canal: A review of 20 melanomas and 29 epidermoid carcinomas (1930 to 1965)Diseases of the Colon & Rectum, 1967