Metalloantibiotics: Synthesis and Antibacterial Activity of Cobalt(II), Copper(II), Nickel(II) and Zinc(II) Complexes of Kefzol
- 1 February 2004
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 19 (1), 79-84
- https://doi.org/10.1080/14756360310001624939
Abstract
Kefzol (kzl), a β-lactam antibiotic, possesses various donor sites for interaction with transition metal(II) ions [Co(II), Cu(II), Ni(II) and Zn(II)] to form complexes of the type [M(kzl)2]Cl2 and [M(kzl)Cl], with molar ratio of metal: ligand (M:L) of 1:2 and 1:1 respectively. These complexes were prepared and characterized by physicochemical and spectroscopic methods. Their IR and NMR spectra suggest that kefzol potentially acts as a bidentate, tridentate as well as monoanionic tetradentate ligand. The complexes have been screened for antibacterial activity and results were compared with the activity of the uncomplexed antibiotic against Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Proteus mirabilis. The metal complexes were found to be more potent against one or more bacterial species than the uncomplexed kefzol.Keywords
This publication has 26 references indexed in Scilit:
- Synthesis of Biologically Active Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Symmetrically 1,1′‐Disubstituted Ferrocene‐Derived CompoundsSynthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2003
- Antibacterial Schiff Bases of Oxalyl-hydrazine/diamide Incorporating Pyrrolyl and Salicylyl Moieties and of Their Zinc(II) ComplexesJournal of Enzyme Inhibition and Medicinal Chemistry, 2002
- Biologically Active Co(II) and Ni(II) Complexes of N-(2-Thienylmethylene)-2-AminothiadiazoleMetal-Based Drugs, 2002
- Antibacterial Co(II) and Ni(II) Complexes of N-(2-Furanylmethylene)-2-Aminothiadiazole and Role of , , and anions on Biological PropertiesMetal-Based Drugs, 2002
- Antibacterial Role of , , and Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff BaseMetal-Based Drugs, 2002
- Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff BasesMetal-Based Drugs, 2001
- Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial PropertiesMetal-Based Drugs, 2001
- SYNTHESIS AND CHARACTERIZATION OF Zn(H) COMPLEXES WITH SOME ACYLHYDRAZINE SCHIFF BASESMain Group Metal Chemistry, 2001
- Cephalosporins in the Treatment of MeningitisDrugs, 1987
- Pharmacokinetic Properties of the CephalosporinsDrugs, 1987