Biologically Active Co(II) and Ni(II) Complexes of N-(2-Thienylmethylene)-2-Aminothiadiazole
Open Access
- 1 January 2002
- journal article
- research article
- Published by Hindawi Limited in Metal-Based Drugs
- Vol. 8 (6), 323-327
- https://doi.org/10.1155/mbd.2002.323
Abstract
Co(II) and Ni(II) complexes Schiff base, N-(2-thienylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, where M=Co(II) or Ni(II), L=, X= , , or and n=1 or 2 and show an octahedral geometry. In order to evaluate the effect anions upon chelation, the Schiff-base and its new complexes have been screened for their antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.