Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes
Open Access
- 1 February 2012
- journal article
- research article
- Published by Hindawi Limited in Bioinorganic Chemistry and Applications
- Vol. 2012, 1-6
- https://doi.org/10.1155/2012/795812
Abstract
Metal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities. The free-radical-scavenging ability of the metal complexes was determined by their interaction with the stable free radical 2,2′′-diphenyl-1-picrylhydrazyl, and all the compounds showed encouraging antioxidant activities. DFT calculations of the Cu complex were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.Keywords
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