Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies
Open Access
- 30 December 2010
- journal article
- research article
- Published by Hindawi Limited in Bioinorganic Chemistry and Applications
- Vol. 2010, 1-9
- https://doi.org/10.1155/2010/854514
Abstract
Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes1and3with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes1and3with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex1can act as effective DNA cleaving agent when compared to complex3resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.Keywords
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