The rat delta‐1 and delta‐2 subunits extend the excitatory amino acid receptor family
- 11 January 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 315 (3), 318-322
- https://doi.org/10.1016/0014-5793(93)81186-4
Abstract
We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.Keywords
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