Protective effect of total and supplemental vitamin C intake on the risk of hip fracture—a 17-year follow-up from the Framingham Osteoporosis Study
- 4 April 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Osteoporosis International
- Vol. 20 (11), 1853-1861
- https://doi.org/10.1007/s00198-009-0897-y
Abstract
Vitamin C may play a role in bone health. In the Framingham Study, subjects with higher total or supplemental vitamin C intake had fewer hip fractures and non-vertebral fractures as compared to subjects with lower intakes. Therefore, vitamin C may have a protective effect on bone health in older adults. Dietary antioxidants such as vitamin C may play a role in bone health. We evaluated associations of vitamin C intake (total, dietary, and supplemental) with incident hip fracture and non-vertebral osteoporotic fracture, over a 15- to 17-year follow-up, in the Framingham Osteoporosis Study. Three hundred and sixty-six men and 592 women (mean age 75 ± 5 years) completed a food frequency questionnaire (FFQ) in 1988–1989 and were followed for non-vertebral fracture until 2003 and hip fracture until 2005. Tertiles of vitamin C intake were created from estimates obtained using the Willett FFQ, after adjusting for total energy (residual method). Hazard ratios were estimated using Cox-proportional hazards regression, adjusting for covariates. Over follow-up 100 hip fractures occurred. Subjects in the highest tertile of total vitamin C intake had significantly fewer hip fractures (P trend = 0.04) and non-vertebral fractures (P trend = 0.05) compared to subjects in the lowest tertile of intake. Subjects in the highest category of supplemental vitamin C intake had significantly fewer hip fractures (P trend = 0.02) and non-vertebral fractures (P trend = 0.07) compared to non-supplement users. Dietary vitamin C intake was not associated with fracture risk (all P > 0.22). These results suggest a possible protective effect of vitamin C on bone health in older adults.Keywords
This publication has 47 references indexed in Scilit:
- Prevention and management of osteoporosis.2003
- Antioxidant and redox regulation of gene transcriptionThe FASEB Journal, 1996
- Scurvy results in decreased collagen synthesis and bone density in the guinea pig animal modelBone, 1996
- The worldwide problem of osteoporosis: Insights afforded by epidemiologyBone, 1995
- Alcohol Intake and Bone Mineral Density in Elderly Men and WomenAmerican Journal of Epidemiology, 1995
- Estrogen Replacement Therapy and Fractures in Older WomenAnnals of Internal Medicine, 1995
- Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient statusThe American Journal of Clinical Nutrition, 1993
- Nitroblue tetrazolium reduction and bone resorption by osteoclasts in vitro inhibited by a manganese-based superoxide dismutase mimicJournal of Bone and Mineral Research, 1992
- Reproducibility and Validity of an Expanded Self-Administered Semiquantitative Food Frequency Questionnaire among Male Health ProfessionalsAmerican Journal of Epidemiology, 1992
- Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)Free Radical Research Communications, 1992