Genetics of disc degeneration
Open Access
- 4 July 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in European Spine Journal
- Vol. 15 (S3), 317-325
- https://doi.org/10.1007/s00586-006-0171-3
Abstract
Low back pain from degenerative disc disease (DDD) is one of the most common disorders seen in general and orthopaedic practices. DDD has been attributed to the accumulation of environmental factors, primarily mechanical insults and injuries, imposed on the “normal” aging changes. However, recent studies have shown an association between genetic influences and disc degeneration, with risk of developing DDD quoted to be increased up to six times that of the general population. It is likely that DDD is a complex, multifactorial disease determined by the interplay between gene(s) and the environment. This review focuses on the evidence for genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition.Keywords
This publication has 75 references indexed in Scilit:
- A haplotype map of the human genomeNature, 2005
- Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ß gene polymorphismsEuropean Spine Journal, 2005
- Complement Factor H Polymorphism in Age-Related Macular DegenerationScience, 2005
- COL9A3 Gene Polymorphism and Obesity in Intervertebral Disc Degeneration of the Lumbar Spine: Evidence of Gene-Environment InteractionSpine, 2002
- Abnormal sulfate metabolism in vitamin D-deficient rats.JCI Insight, 1997
- Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.JCI Insight, 1997
- Vitamin D–Receptor Genotypes and Bone DensityNew England Journal of Medicine, 1997
- Determinants of Lumbar Disc DegenerationSpine, 1995
- Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.Heart, 1995
- Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.JCI Insight, 1994