Vitamin D–Receptor Genotypes and Bone Density

Abstract

Bone density is known to have strong genetic determinants. On the basis of studies of twins and mother–daughter pairs, it is estimated that heredity accounts for up to 70 percent of the variance in bone density in both women and men.¹ Thus, the identification of the genes that mediate these heritable effects could lead to a better understanding of the pathogenesis of osteoporosis, a means to identify those at risk for this disease, and more rational ways to prevent and treat it.One candidate is the gene for the vitamin D receptor, because the vitamin D–endocrine system controls multiple aspects . . .