Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers
Top Cited Papers
- 6 October 2009
- journal article
- review article
- Published by Taylor & Francis Ltd in Critical Reviews in Clinical Laboratory Sciences
- Vol. 46 (5-6), 241-281
- https://doi.org/10.3109/10408360903142326
Abstract
Oxidative stress has been related increasingly to the onset and/or progression of a growing number of human diseases. However, large studies on supplementation with anti-oxidants for prevention or treatment of different pathologies have yielded contradictory and mostly negative results, as documented by numerous meta-analyses and clinical trials. Here we analyze in detail the findings of these studies and discuss major aspects that, in our opinion, are likely to be responsible for these confounding data. With the belief that a clear correlation between disease and oxidative stress is far from being proven for most pathological conditions, our argument focuses on the following points: i) choice of biomarker(s) and/or the biological system(s) for the analyses; ii) pitfalls in pre-analytical and analytical methods for assessing oxidative stress; and iii) scientific misconduct. Eventually, suggestions aiming to obtain more convergent results on this topic are provided.Keywords
This publication has 281 references indexed in Scilit:
- A Randomized Factorial Trial of Vitamins C and E and Beta Carotene in the Secondary Prevention of Cardiovascular Events in WomenArchives of Internal Medicine, 2007
- Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary PreventionJama-Journal Of The American Medical Association, 2007
- Fruit and vegetable juices and Alzheimer's disease: The Kame ProjectAmerican Journal Of Medicine, 2006
- Age-dependent oxidative stress-induced DNA damage in Down’s lymphocytesBiochemical and Biophysical Research Communications, 2006
- Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infantsThe Journal of Pediatrics, 2006
- Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humansBiochemical and Biophysical Research Communications, 2006
- Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolismBirth Defects Research Part A: Clinical and Molecular Teratology, 2006
- Interdependency of the oxidizability of lipoproteins and peroxidase activity with base excess, HCO3, pH and magnesium in human venous and capillary bloodLife Sciences, 2006
- Passive cigarette smoking increases isoprostane formationLife Sciences, 2006
- A review of approaches to the analysis of 3-nitrotyrosineAmino Acids, 2003