Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity
- 16 August 2012
- journal article
- Published by Wiley in Phytotherapy Research
- Vol. 27 (6), 852-858
- https://doi.org/10.1002/ptr.4807
Abstract
With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose‐dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem‐x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated. Copyright © 2012 John Wiley & Sons, Ltd.Keywords
This publication has 29 references indexed in Scilit:
- Chamomile, an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activityInternational Journal of Molecular Medicine, 2010
- Titanium(IV) carboxylate complexes: Synthesis, structural characterization and cytotoxic activityPolyhedron, 2010
- Altitudinal Variation of Secondary Metabolite Profiles in Flowering Heads of Matricaria chamomilla cv. BONAPlanta Medica, 2008
- Molecular targets of dietary agents for prevention and therapy of cancerBiochemical Pharmacology, 2006
- A new extract of the plant calendula officinalis produces a dual in vitroeffect: cytotoxic anti-tumor activity and lymphocyte activationBMC Cancer, 2006
- Biological activities of berries: From antioxidant capacity to anti‐cancer effectsBioFactors, 2005
- Antioxidant properties of marigold extractsFood Research International, 2004
- Anticancer Activity of Phenolic Acids of Natural or Synthetic Origin: A Structure−Activity StudyJournal of Medicinal Chemistry, 2003
- Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissimaCancer Letters, 1999
- Anti-HIV activity of extracts from Calendula officinalis flowersBiomedicine & Pharmacotherapy, 1997