Genetics of Redox Systems and Their Relationship with Cardiovascular Disease
- 4 March 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Current Atherosclerosis Reports
- Vol. 13 (3), 215-224
- https://doi.org/10.1007/s11883-011-0170-7
Abstract
As atherosclerosis is still one of the major causes of death in Western populations, it is important to identify those individuals who are at increased risk for the disease so that aggressive treatment may be administered as early as possible. Following the understanding that oxidative stress has a pivotal role in the development and progression of atherosclerosis, many polymorphisms in genes that are related to redox systems were examined for their association with increased risk for cardiovascular disease (CVD). Although many polymorphisms were studied, only a handful showed consistent relevance to CVD in different trials. This article focuses on six of these polymorphisms, examining their effect on the risk for CVD as well as their effect on protein expression and function. Reports regarding pharmacogenetic implications of these polymorphisms, where such exist, are discussed as well.This publication has 76 references indexed in Scilit:
- Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysisGenetics in Medicine, 2010
- The Genetics of Vascular Complications in Diabetes MellitusCardiology Clinics, 2010
- Regulation of superoxide dismutase genes: Implications in diseaseFree Radical Biology & Medicine, 2009
- Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy PopulationCirculation: Cardiovascular Genetics, 2009
- Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular DiseaseJAMA, 2008
- Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular RiskJAMA, 2008
- Life history of eNOS: Partners and pathwaysCardiovascular Research, 2007
- Promoter Polymorphisms in the Plasma Glutathione Peroxidase ( GPx-3 ) GeneStroke, 2007
- Polymorphisms in endothelial nitric oxide synthase and carotid artery atherosclerosisJournal of Clinical Pathology, 2006
- Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?BMJ, 2005