Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk

Abstract

Systemic oxidative stress promotes a number of key events in the development of atherosclerosis, and the search to identify effective therapeutic antioxidant strategies is of potential clinical interest. For example, in addition to promoting reverse cholesterol transport, high-density lipoprotein (HDL) is also reported to promote systemic anti-inflammatory and antioxidant effects. The HDL associated esterase/lactonase paraoxonase 1 (PON1) is implicated in contributing to the anti-inflammatory and antioxidant activities of the lipoprotein,¹ although direct demonstration of this in humans is lacking.