Pathway to Artificial Pancreas Systems Revisited: Moving Downstream
Open Access
- 12 May 2015
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 38 (6), 1036-1043
- https://doi.org/10.2337/dc15-0364
Abstract
Artificial pancreas (AP) systems, a long-sought quest to replicate mechanically islet physiology that is lost in diabetes, are reaching the clinic, and the potential of automating insulin delivery is about to be realized. Significant progress has been made, and the safety and feasibility of AP systems have been demonstrated in the clinical research center and more recently in outpatient “real-world” environments. An iterative road map to AP system development has guided AP research since 2009, but progress in the field indicates that it needs updating. While it is now clear that AP systems are technically feasible, it remains much less certain that they will be widely adopted by clinicians and patients. Ultimately, the true success of AP systems will be defined by successful integration into the diabetes health care system and by the ultimate metric: improved diabetes outcomes.Keywords
This publication has 40 references indexed in Scilit:
- Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D Exchange clinic registryPediatric Diabetes, 2013
- Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes CampThe New England Journal of Medicine, 2013
- Effect of Pramlintide on Prandial Glycemic Excursions During Closed-Loop Control in Adolescents and Young Adults With Type 1 DiabetesDiabetes Care, 2012
- Fully Integrated Artificial Pancreas in Type 1 DiabetesDiabetes, 2012
- Physiologic action of glucagon on liver glucose metabolismDiabetes, Obesity and Metabolism, 2011
- Psychosocial Well-Being and Functional Outcomes in Youth With Type 1 Diabetes 12 years After Disease OnsetDiabetes Care, 2010
- Variation of Interstitial Glucose Measurements Assessed by Continuous Glucose Monitors in Healthy, Nondiabetic IndividualsDiabetes Care, 2010
- Continuous Glucose Monitoring and Intensive Treatment of Type 1 DiabetesThe New England Journal of Medicine, 2008
- Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial PancreasDiabetes Care, 2008
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusThe New England Journal of Medicine, 1993