Combined Therapy of Major Depression with Concomitant Borderline Personality Disorder: Comparison of Interpersonal and Cognitive Psychotherapy
Open Access
- 1 November 2007
- journal article
- research article
- Published by SAGE Publications in The Canadian Journal of Psychiatry
- Vol. 52 (11), 718-725
- https://doi.org/10.1177/070674370705201106
Abstract
The combination of antidepressants and brief psychotherapies has been proven more efficacious in treating major depression and is particularly recommended in patients with concomitant personality disorders. We compare the effects of 2 combined therapies, fluoxetine and interpersonal therapy (IPT) or fluoxetine and cognitive therapy (CT), on major depression in patients with borderline personality disorder (BPD). Thirty-five consecutive outpatients with a diagnosis of BPD and a major depressive episode (not bipolar and not psychotic) were enrolled. They were randomly assigned to 1 of the 2 combined treatments and treated for 24 weeks. Assessment included a semistructured interview, Clinical Global Impression (CGI) scale, Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Beck Depression Inventory-II (BDI-II), Social and Occupational Functioning Assessment Scale (SOFAS), Satisfaction Profile (SAT-P) for quality of life (QOL), and Inventory of Interpersonal Problems (IIP-64). Statistical analysis was performed using the univariate General Linear Model to calculate the effects of duration and type of treatment. No significant differences between treatments were found at CGI, HDRS, BDI-II, and SOFAS score. Combined treatment with CT had greater effects on HARS score and on psychological functioning factor of SAT-P. Combined treatment with IPT was more effective on social functioning factor of SAT-P and on domains domineering or controlling and intrusive or needy of IIP-64. Both combined therapies are efficacious in treating major depression in patients with BPD. Differences between CT and IPT concern specific features of subjective QOL and interpersonal problems. These findings lack reliable comparisons and need to be replicated.Keywords
This publication has 56 references indexed in Scilit:
- Dysfunctional attitudes and personality disorder comorbidity during long-term treatment of MDDDepression and Anxiety, 2007
- Recent non-medication trials of interpersonal psychotherapy for depressionInternational Journal of Neuropsychopharmacology, 2006
- Utilization of psychotherapy in patients with personality disorder: The impact of gender, character traits, affect regulation, and quality of object-relationsPsychology and Psychotherapy: Theory, Research and Practice, 2005
- The Güttingen study of psychoanalytic therapy: First resultsThe International Journal of Psychoanalysis, 2005
- Personality pathology and outcome in recurrently depressed women over 2 years of maintenance interpersonal psychotherapyPsychological Medicine, 2004
- Wirksamkeit und Wirkfaktoren der interpersonellen Psychotherapie in der stationären Depressionsbehandlung - Ergebnisse einer PilotstudiePPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie, 2004
- Interpersonal psychotherapy for chronic depressionJournal of Clinical Psychology, 2003
- Interpersonal problems, personality pathology, and social adjustment after cognitive therapy for depression.Psychological Assessment, 2003
- A component analysis of cognitive-behavioral therapy for generalized anxiety disorder and the role of interpersonal problems.Journal of Consulting and Clinical Psychology, 2002
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960