Transient and selective suppression of neural activity with infrared light
Open Access
- 6 September 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 3 (1), srep02600
- https://doi.org/10.1038/srep02600
Abstract
Analysis and control of neural circuitry requires the ability to selectively activate or inhibit neurons. Previous work showed that infrared laser light selectively excited neural activity in endogenous unmyelinated and myelinated axons. However, inhibition of neuronal firing with infrared light was only observed in limited cases, is not well understood and was not precisely controlled. Using an experimentally tractable unmyelinated preparation for detailed investigation and a myelinated preparation for validation, we report that it is possible to selectively and transiently inhibit electrically-initiated axonal activation, as well as to both block or enhance the propagation of action potentials of specific motor neurons. Thus, in addition to previously shown excitation, we demonstrate an optical method of suppressing components of the nervous system with functional spatiotemporal precision. We believe this technique is well-suited for non-invasive investigations of diverse excitable tissues and may ultimately be applied for treating neurological disorders.This publication has 33 references indexed in Scilit:
- Optical inhibition of motor nerve and muscle activity in vivoMuscle & Nerve, 2012
- The Development and Application of OptogeneticsAnnual Review of Neuroscience, 2011
- Spatial steering of deep brain stimulation volumes using a novel lead designClinical Neurophysiology, 2011
- Neural stimulation with optical radiationLaser & Photonics Reviews, 2010
- Implantable brain computer interface: Challenges to neurotechnology translationNeurobiology of Disease, 2010
- Implanted Neural Interfaces: Biochallenges and Engineered SolutionsAnnual Review of Biomedical Engineering, 2009
- Noncontact Stimulation of the Cavernous Nerves in the Rat Prostate Using a Tunable-Wavelength Thulium Fiber LaserJournal of Endourology, 2008
- Peripheral Nerve Stimulation for Neuropathic PainNeurotherapeutics, 2008
- Laser stimulation of the auditory nerveLasers in Surgery and Medicine, 2006
- Functional Electrical Stimulation for Neuromuscular ApplicationsAnnual Review of Biomedical Engineering, 2005