Mature cystic teratomas arise from meiotic oocytes, but not from pre‐meiotic oogonia
- 21 January 2016
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 55 (4), 355-364
- https://doi.org/10.1002/gcc.22339
Abstract
Mature cystic teratomas (MCTs) in the ovaries have been thought to originate from germ cells from all developmental stages, i.e., from pre-meiotic oogonia through meiotic oocytes to mature post-meiotic ova. This view was based on research on MCTs by classical methods, including those involving centromeric heteromorphisms in karyotypes, enzyme polymorphisms, and DNA polymorphisms. However, insufficient genomic information was obtained in those studies. The current study aimed to confirm the cytogenetic origin of ovarian MCTs by using short tandem repeat (STR) polymorphism analysis to obtain sufficient genomic information, especially in connection with centromeric loci. Tissue samples of MCTs (57 ovaries from 51 patients, 91 MCTs, 156 specimens in total) obtained from cystectomies or oophorectomies were used. We categorized the specimens into two groups: i) solid components of MCTs and ii) cyst walls. The numbers of solid components of MCTs from pre-meiotic oogonia, primary oocytes, secondary oocytes, and ova were 0, 33, 16, and 15, respectively. There were no pre-meiotic oogonia in this series of solid-component specimens. We propose a hypothesis for the tumorigenesis of ovarian MCTs: the precursors of ovarian MCTs are not functional oocytes or ova, but are primary oocytes that have escaped from meiotic arrest. This hypothesis could satisfactorily explain the lack of pre-meiotic teratomas observed in this study and the nearly equal distribution of teratomas originating from primary oocytes, secondary oocytes, and ova in previous studies. Furthermore, this hypothesis could provide a starting point for determining the mechanism underlying tumorigenesis of ovarian MCTs.Keywords
This publication has 18 references indexed in Scilit:
- Ovarian mucinous tumors arising from mature cystic teratomas—a molecular genetic approach for understanding the cellular originHuman Pathology, 2013
- Reprogramming in vivo produces teratomas and iPS cells with totipotency featuresNature, 2013
- Matching Maternal Isodisomy in Mucinous Carcinomas and Associated Ovarian Teratomas Provides Evidence of Germ Cell Derivation for Some Mucinous Ovarian TumorsThe American Journal of Surgical Pathology, 2013
- The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform molesHuman Reproduction, 2010
- Genetics and Genomics of Core Short Tandem Repeat Loci Used in Human Identity TestingJournal of Forensic Sciences, 2006
- The G s -Linked Receptor GPR3 Maintains Meiotic Arrest in Mammalian OocytesScience, 2004
- Validation of a 16-Locus Fluorescent Multiplex SystemJournal of Forensic Sciences, 2002
- Methylation Imprinting of H19 and SNRPN Genes in Human Benign Ovarian TeratomasAmerican Journal of Human Genetics, 1999
- Diverse origins of multiple ovarian teratomas in a single individual.Proceedings of the National Academy of Sciences of the United States of America, 1982
- Parthenogenic Origin of Benign Ovarian TeratomasThe New England Journal of Medicine, 1975