Superoxide dismutase induces differentiation of friend erythroleukemia cells
- 1 May 1989
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 139 (2), 370-376
- https://doi.org/10.1002/jcp.1041390220
Abstract
Friend erythroleukemia cells (FELC) served as a model system for cell differentiation because these cells can be triggered to differentiate by a variety of chemical agents. Treatment with the classical inducer of differentiation, hexamethylene bisacetamide (HMBA), stimulated superoxide dismutase (SOD) activity, which increased in parallel with HMBA-induced differentiation. Furthermore, FELC were shown to differentiate in response to the addition of liposomes containing SOD. Oxidative treatment with Iiposomes containing D-amino acid oxidase or xanthine oxidase, cumene peroxide, or potassium superoxide also induced differentiation, whereas antioxidants such as a-tocopherol, butylated hydroxytoluene, or p-carotene did not induce differentiation. Also, HMBA induction of differentiation was suppressed by treatment with antioxidants.Keywords
This publication has 38 references indexed in Scilit:
- Superoxide dismutase activity and glutathione concentration during the calcium-induced differentiation ofPhysarum polycephalum microplasmodiaJournal of Cellular Physiology, 1987
- Oxygen free radicals play a role in cellular differentiation: An hypothesisJournal of Free Radicals in Biology & Medicine, 1986
- Inhibition of dimethylsulfoxide-induced differentiation in friend erythroleukemic cells by diacylglycerols and phospholipase CBiochemical and Biophysical Research Communications, 1984
- The role of cytoskeletal integrity in cellular transformationJournal of Theoretical Biology, 1984
- Enzymes involved in oxygen detoxification during development ofDrosophila melanogasterCellular and Molecular Life Sciences, 1983
- Multinucleation and inhibition of cytokinesis in suspended cells: Reversal upon reattachment to a substrateCell, 1981
- Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblastsCell, 1980
- Cell differentation, aging and cancer: The possible roles of superoxide and superoxide dismutasesMedical Hypotheses, 1980
- Sulfhydryl groups and the differentiation of murine erythroleukemia cellsBiochemical and Biophysical Research Communications, 1979
- Variation of superoxide dismutases during the development of the fruit fly Ceratitis capitata LBiochemical and Biophysical Research Communications, 1976