A systematic review of experimental and clinical studies of sildenafil citrate for intrauterine growth restriction and pre-term labour
- 1 January 2007
- journal article
- review article
- Published by Taylor & Francis Ltd in Journal of Obstetrics and Gynaecology
- Vol. 27 (3), 255-259
- https://doi.org/10.1080/01443610701194978
Abstract
Sildenafil could be an alternative in the treatment of intrauterine growth retardation (IUGR) and premature delivery. In order to systematically review the reproductive-related effects of sildenafil, a search was made on PubMed and the Science Citation Index for studies evaluating the effects of sildenafil on uterine vessels or myometrium either in vitro or in experimental animal models as well as for any clinical trial or case reporting the outcome of pregnant women treated with sildenafil. The information was obtained from: three in vitro studies, five studies performed in experimental animal models, four studies on women with fertility and sterility disorders receiving 100 mg/day of sildenafil intravaginally, and two case reports of pregnant women who received sildenafil for the treatment of pulmonary hypertension. Incubation with sildenafil of different in vitro preparations resulted in vasodilator and uterine relaxant effects. No evidence of teratogenicity was observed in the studies performed in mice, rats and dogs. Sildenafil increased fetal weight in rats. In women, contradictory results on uterine blood flow and endometrial development were reported after the intravaginal administration of sildenafil. No adverse fetal outcomes were reported in the two pregnant women with pulmonary hypertension receiving sildenafil late in their pregnancy. In conclusion, there is still limited information about the efficacy of sildenafil for the treatment of IUGR and premature delivery. However, studies in experimental animal models and two human case reports have reported no deleterious effects on the mother or offspring.Keywords
This publication has 25 references indexed in Scilit:
- Atosiban and nifedipine in acute tocolysis: A comparative studyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2006
- Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyondNature Reviews Drug Discovery, 2006
- Preclinical safety profile of sildenafilInternational Journal of Impotence Research, 2004
- The presence and function of phosphodiesterase type 5 in the rat myometriumAmerican Journal of Obstetrics and Gynecology, 2004
- Survival and Long-Term Neurodevelopmental Outcome of Extremely Premature Infants Born at 23–26 Weeks’ Gestational Age at a Tertiary CenterPEDIATRICS, 2004
- Regulation of Fetal Growth by the Somatotrophic AxisJournal of Nutrition, 2003
- Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized womenBMC Pregnancy and Childbirth, 2002
- Sildenafil inhibits agonist-evoked rat uterine contractility: influence of guanylyl cyclase inhibitionEuropean Journal of Pharmacology, 2001
- Cyclic GMP Phosphodiesterase-5: Target of SildenafilOnline Journal of Public Health Informatics, 1999
- EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMESJournal of Urology, 1998