Cyclic GMP Phosphodiesterase-5: Target of Sildenafil
Open Access
- 1 May 1999
- journal article
- review article
- Published by Elsevier BV
- Vol. 274 (20), 13729-13732
- https://doi.org/10.1074/jbc.274.20.13729
Abstract
No abstract availableThis publication has 46 references indexed in Scilit:
- Ligand-Induced Conformational Changes in Cyclic Nucleotide Phosphodiesterases and Cyclic Nucleotide-Dependent Protein KinasesMethods, 1998
- Zinc Dependent Activation of cAMP-Specific Phosphodiesterase (PDE4A)Biochemical and Biophysical Research Communications, 1997
- The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP PhosphodiesterasePublished by Elsevier BV ,1997
- Identification of Key Amino Acids in a Conserved cGMP-binding Site of cGMP-binding PhosphodiesterasesPublished by Elsevier BV ,1996
- Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctionBioorganic & Medicinal Chemistry Letters, 1996
- An Essential Aspartic Acid at Each of Two Allosteric cGMP-binding Sites of a cGMP-specific PhosphodiesterasePublished by Elsevier BV ,1995
- Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymesCellular Signalling, 1994
- Phosphorylation of the 61-kDa Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase at Serine 120 Reduces Its Affinity for CalmodulinBiochemistry, 1994
- Nitric Oxide: A Physiologic Mediator of Penile ErectionScience, 1992
- Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferensNature, 1977