Comparison of Clinical and Spectral Domain Optical Coherence Tomography Optic Disc Margin Anatomy
Open Access
- 1 October 2009
- journal article
- research article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Ophthalmology & Visual Science
- Vol. 50 (10), 4709-4718
- https://doi.org/10.1167/iovs.09-3586
Abstract
To investigate spectral domain optical coherence tomography (SD-OCT) detected optic disc margin anatomy in the monkey eye by co-localizing disc photographs to SD-OCT scans acquired from the same eyes. The neural canal opening (NCO) was delineated within 40 digital radial sections generated from SD-OCT volumes acquired from 33 normal monkey eyes (15°, 290 × 768 horizontal grid pattern, Heidelberg Spectralis). Each volume was co-localized to its disc photograph by matching the retinal vessels within each photograph to vessel outlines visible within en face SD-OCT images. Border Tissue was delineated where it extended internal to the NCO. A clinician (masked to delineated points) marked the disc margin onto each photograph whilst viewing the relevant stereophotograph pair. Alignment of the clinician-ascribed disc margin to the NCO and Border Tissue delineations was assessed. The process was repeated in a single myopic human eye. In 23 eyes, the NCO aligned to the disc margin. In 10 eyes, externally oblique Border Tissue was detectable in the temporal disc. In these regions of the disc, the termination of Border Tissue was the disc margin. An exaggerated form of this phenotype was observed in the myopic human eye. In this case, temporal Border Tissue terminated at the anterior scleral canal opening, which was detected as the disc margin. The termination of Bruch’s Membrane, Border Tissue and the anterior scleral canal opening may constitute the disc margin within the same eye depending upon the Border Tissue architecture; this anatomy is consistently visualized by SD-OCT.This publication has 16 references indexed in Scilit:
- Comparison of Spectral Domain Optical Coherence Tomography and Color Photographic Imaging of the Optic Nerve Head in Management of GlaucomaOphthalmic Surgery, Lasers and Imaging Retina, 2009
- Comparison of Clinical and Three-Dimensional Histomorphometric Optic Disc Margin AnatomyInvestigative Ophthalmology & Visual Science, 2009
- Relative Course of Retinal Nerve Fiber Layer Birefringence and Thickness and Retinal Function Changes after Optic Nerve TransectionInvestigative Ophthalmology & Visual Science, 2008
- State-of-the-art retinal optical coherence tomographyProgress in Retinal and Eye Research, 2008
- Three-Dimensional Histomorphometry of the Normal and Early Glaucomatous Monkey Optic Nerve Head: Neural Canal and Subarachnoid Space ArchitectureInvestigative Ophthalmology & Visual Science, 2007
- Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patientsJournal of Biomedical Optics, 2007
- Three-Dimensional Reconstruction of Normal and Early Glaucoma Monkey Optic Nerve Head Connective TissuesInvestigative Ophthalmology & Visual Science, 2004
- Optimal wavelength for ultrahigh-resolution optical coherence tomographyOptics Express, 2003
- Clinical Histologic Correlation of Human Peripapillary AnatomyOphthalmology, 1989
- The Configuration of Peripapillary Tissue in Unilateral GlaucomaAmerican Journal of Ophthalmology, 1988