Comparison of Spectral Domain Optical Coherence Tomography and Color Photographic Imaging of the Optic Nerve Head in Management of Glaucoma

Abstract

Imaging: Clinical Science Yuriko Kotera, MD; Yoshiaki Yasuno, PhD; Masanori Hangai, MD, PhD; Ryo Inoue, MD; Suichi Makita, MS; Hideo Nakanishi, MD; Masahiro Yamanari, MS; Nagahisa Yoshimura, MD, PhD Spectral domain optical coherence tomography (SD-OCT) allows three-dimensional imaging of the optic disc. The objective of this study was to compare optic disc and cup margins between fundus photographs and SD-OCT. Eighteen eyes with glaucoma were examined by a custom-built SD-OCT. OCT fundus images were used to register fundus photographs and SD-OCT volume. Disc margins on fundus photographs corresponded to termination of the highly reflective straight line that represented the retinal pigment epithelium (RPE) or the highly reflective curved line that connected to the RPE on the OCT B-scan images at 99.3% of the positions along the disc edges. Cup margins on fundus photographs corresponded at 73.6% of the positions to the interior border of the hyporeflective regions on the OCT fundus images. Excellent to fair correspondence in the determination of disc and cup margins between fundus photographs and SD-OCT images was shown. [Ophthalmic Surg Lasers Imaging 2009;40:255-263.] From the Department of Ophthalmology and Visual Sciences (YK, MH, RI, HN, NY), Kyoto University Graduate School of Medicine, Kyoto; and the Computational Optics Group (YY, SM, MY), University of Tsukuba, Ibaraki, Japan. Accepted for publication April 17, 2008. Presented in part at the Association for Research in Vision and Ophthalmology annual meeting, May 6-10, 2007, Fort Lauderdale, Florida. Supported in part by a Grant-in-aid for Scientific Research (15760026) from the Japan Society for the Promotion of Science; the Japan Science and Technology Agency; the Special Research Project on Nanoscience, University of Tsukuba; and TOPCON, Tokyo, Japan (YY, SM, MY). Dr. Makita is supported by the Japan Society for the Promotion of Science through a contract under the Promotion of Creative Interdisciplinary Materials Science for Novel Functions, 21st Century Center of Excellence Program. The authors have no financial or proprietary interest in the materials presented herein. Address correspondence to Masanori Hangai, MD, Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan. 10.9999/15428877-20090430-06 Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. We reserve the right not to post any comments with unsolicited information about medical devices or other products. At no time will Healio be used for medical advice to patients.