Macrophage-Mediated Inflammation and Disease: A Focus on the Lung
Open Access
- 12 December 2012
- journal article
- review article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2012, 1-6
- https://doi.org/10.1155/2012/140937
Abstract
The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution. Cells present in the airways must therefore be maintained in a generally suppressive phenotype so that excessive responses to nonserious irritants do not occur; these result in bystander damage to lung architecture, influx of immune cells to the airways, and consequent impairment of gas exchange. To this end, the resident cells of the lung, which are predominantly macrophages, are kept in a dampened state. However, on occasion the suppression fails and these macrophages overreact to antigenic challenge, resulting in release of inflammatory mediators, induction of death of lung epithelial cells, deposition of extracellular matrix, and development of immunopathology. In this paper, we discuss the mechanisms behind this macrophage-mediated pathology, in the context of a number of inflammatory pulmonary disorders.Keywords
This publication has 49 references indexed in Scilit:
- Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus InfectionJournal of Virology, 2012
- Lowering the Threshold of Lung Innate Immune Cell Activation Alters Susceptibility to Secondary Bacterial SuperinfectionThe Journal of Infectious Diseases, 2011
- Integrating mechanisms of pulmonary fibrosisThe Journal of Experimental Medicine, 2011
- MCP-1 Antibody Treatment Enhances Damage and Impedes Repair of the Alveolar Epithelium in Influenza PneumonitisAmerican Journal of Respiratory Cell and Molecular Biology, 2010
- Lung environment determines unique phenotype of alveolar macrophagesAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2009
- Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligandThe Journal of Experimental Medicine, 2008
- Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPαAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Monocyte-Mediated Defense Against Microbial PathogensAnnual Review of Immunology, 2008
- Activation of Alveolar Macrophages via the Alternative Pathway in Herpesvirus-Induced Lung FibrosisAmerican Journal of Respiratory Cell and Molecular Biology, 2006
- Alternative activation of macrophagesNature Reviews Immunology, 2003