Integrating mechanisms of pulmonary fibrosis
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Open Access
- 4 July 2011
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 208 (7), 1339-1350
- https://doi.org/10.1084/jem.20110551
Abstract
Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has frequently focused on the mechanisms that regulate the proliferation, activation, and differentiation of collagen-secreting myofibroblasts, recent studies have identified new pathogenic mechanisms that are critically involved in the initiation and progression of fibrosis in a variety of settings. A more detailed and integrated understanding of the cellular and molecular mechanisms of pulmonary fibrosis could help pave the way for effective therapeutics for this devastating and complex disease.Keywords
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