Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R
Top Cited Papers
- 1 April 2007
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 153 (4), 1042-1058
- https://doi.org/10.1099/mic.0.2006/003657-0
Abstract
The complete genome sequence of Corynebacterium glutamicum strain R was determined to allow its comparative analysis with other corynebacteria. The biology of corynebacteria was explored by refining the definition of the subset of genes that constitutes the corynebacterial core as well as those characteristic of saprophytic and pathogenic ecological niches. In addition, the relative scarcity of corynebacterial sigma factors and the plasticity of their two-component system machinery reflect their relatively exacting nutritional requirements and reduced membrane-associated and secreted proteins. The conservation of key genes and pathways between corynebacteria, mycobacteria and Nocardia validates the use of C. glutamicum to study fundamental processes that are conserved in slow-growing mycobacteria, including pathogenesis-associated mechanisms. The discovery of 39 novel genes in C. glutamicum R that have not been previously reported in other corynebacteria supports the rationale for sequencing additional corynebacterial genomes to better define the corynebacterial pan-genome and identify previously undetected metabolic pathways in these organisms.Keywords
This publication has 87 references indexed in Scilit:
- The MicrobesOnline Web site for comparative genomicsGenome Research, 2005
- The Mycobacterium tuberculosis SigD sigma factor controls the expression of ribosome-associated gene products in stationary phase and is required for full virulenceCellular Microbiology, 2004
- The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129Nucleic Acids Research, 2003
- Mycobacterium bovisBCG Response Regulator Essential for Hypoxic DormancyJournal of Bacteriology, 2002
- Identification and characterization of the non-PTS fru locus of Bacillus megaterium ATCC 14581Molecular Genetics and Genomics, 2002
- GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regionsNucleic Acids Research, 2001
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- The Complete Genome Sequence of Escherichia coli K-12Science, 1997
- A new DNA sequence assembly programNucleic Acids Research, 1995
- Identification of IS 1206, a Corynebacterium glutamicum IS3‐related insertion sequence and phylogenetic analysisMolecular Microbiology, 1994