Hyperadiponectinemia enhances bone formation in mice
Open Access
- 17 January 2011
- journal article
- Published by Springer Science and Business Media LLC in BMC Musculoskeletal Disorders
- Vol. 12 (1), 18
- https://doi.org/10.1186/1471-2474-12-18
Abstract
Background: There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial.Methods: We therefore investigated the endocrine effects of adiponectin on bone metabolism using 12-week-old male transgenic (Ad-Tg) mice with significant hyperadiponectinemia overexpressing human full-length adiponectin in the liver.Results: In Ad-Tg mice, the serum level of osteocalcin was significantly increased, but the levels of RANKL, osteoprotegerin, and TRAP5b were not. Bone mass was significantly greater in Ad-Tg mice with increased bone formation. In contrast, bone resorption parameters including the number of osteoclasts and eroded surface area did not differ between Ad-Tg and their littermates.Conclusions: These findings demonstrate that hyperadiponectinemia enhances bone formation in mice.This publication has 32 references indexed in Scilit:
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