Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL–RANK signaling system
- 22 November 2005
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 208 (1), 30-49
- https://doi.org/10.1111/j.0105-2896.2005.00327.x
Abstract
Osteoclasts are primary cells for physiological and pathological bone resorption, and receptor activator of nuclear factor-kappaB ligand (RANKL) is critically involved in the differentiation, activation, and survival of these cells. Recently, therapeutics for pathological bone destruction targeting RANKL pathways has attracted a great deal of attention. Herein, we review the recent advances in the research on osteoclast biology and discuss the advantages and disadvantages of anti-RANKL therapies.Keywords
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