Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
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- 6 June 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 300 (5625), 1584-1587
- https://doi.org/10.1126/science.1084677
Abstract
Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N -acetylglucosamine– N -acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-κB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.Keywords
This publication has 27 references indexed in Scilit:
- Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) DetectionJournal of Biological Chemistry, 2003
- Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2Journal of Biological Chemistry, 2003
- Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in DrosophilaScience, 2002
- Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coliNature, 2002
- The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition proteinNature, 2002
- Involvement of receptor-interacting protein 2 in innate and adaptive immune responsesNature, 2002
- Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition proteinNature, 2001
- Toll-like receptors and innate immunityNature Reviews Immunology, 2001
- Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κBJournal of Biological Chemistry, 2001
- Molecular characterization of an autolytic amidase of Listeria monocytogenes EGDMicrobiology, 1998