Adaptive immune responses in acute and chronic hepatitis C virus infection
Top Cited Papers
- 17 August 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 436 (7053), 946-952
- https://doi.org/10.1038/nature04079
Abstract
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.Keywords
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