Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
Open Access
- 6 June 2005
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 201 (11), 1753-1759
- https://doi.org/10.1084/jem.20050122
Abstract
The genomic sequences of viruses that are highly mutable and cause chronic infection tend to diverge over time. We report that these changes represent both immune-driven selection and, in the absence of immune pressure, reversion toward an ancestral consensus. Sequence changes in hepatitis C virus (HCV) structural and nonstructural genes were studied in a cohort of women accidentally infected with HCV in a rare common-source outbreak. We compared sequences present in serum obtained 18–22 yr after infection to sequences present in the shared inoculum and found that HCV evolved along a distinct path in each woman. Amino acid substitutions in known epitopes were directed away from consensus in persons having the HLA allele associated with that epitope (immune selection), and toward consensus in those lacking the allele (reversion). These data suggest that vaccines for genetically diverse viruses may be more effective if they represent consensus sequence, rather than a human isolate.Keywords
This publication has 26 references indexed in Scilit:
- Cellular immune selection with hepatitis C virus persistence in humansThe Journal of Experimental Medicine, 2005
- Accurate Representation of the Hepatitis C Virus Quasispecies in 5.2-Kilobase AmpliconsJournal of Clinical Microbiology, 2004
- Persistence of hepatitis C virus in a white population: Associations with human leukocyte antigen class 1Human Immunology, 2004
- Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defectsJournal of Medical Virology, 2003
- Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population LevelScience, 2002
- Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell AttachmentJournal of Virology, 2001
- Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α TherapyScience, 1998
- Displaying the in formation contents of structural RNA alignments: the structure logosBioinformatics, 1997
- Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.JCI Insight, 1997
- Sequence logos: a new way to display consensus sequencesNucleic Acids Research, 1990