Synthetic Biology: Integrated Gene Circuits
- 2 September 2011
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 333 (6047), 1244-1248
- https://doi.org/10.1126/science.1207084
Abstract
A major goal of synthetic biology is to develop a deeper understanding of biological design principles from the bottom up, by building circuits and studying their behavior in cells. Investigators initially sought to design circuits “from scratch” that functioned as independently as possible from the underlying cellular system. More recently, researchers have begun to develop a new generation of synthetic circuits that integrate more closely with endogenous cellular processes. These approaches are providing fundamental insights into the regulatory architecture, dynamics, and evolution of genetic circuits and enabling new levels of control across diverse biological systems.This publication has 40 references indexed in Scilit:
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