The pedestrian watchmaker: Genetic clocks from engineered oscillators
Open Access
- 10 November 2009
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 583 (24), 3931-3937
- https://doi.org/10.1016/j.febslet.2009.10.089
Abstract
The crucial role of time‐keeping has required organisms to develop sophisticated regulatory networks to ensure the reliable propagation of periodic behavior. These biological clocks have long been a focus of research; however, a clear understanding of how they maintain oscillations in the face of unpredictable environments and the inherent noise of biological systems remains elusive. Here, we review the current understanding of circadian oscillations using Drosophila melanogaster as a typical example and discuss the utility of an alternative synthetic biology approach to studying these highly intricate systems.Keywords
Funding Information
- DOE CSGF (DE-FG02-97ER25308)
- NIH (GM69811-01)
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