QUALITY ISSUES IN INTERPRETATION OF OPTICAL COHERENCE TOMOGRAMS IN MACULAR DISEASES
- 1 June 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Retina
- Vol. 29 (6), 775-781
- https://doi.org/10.1097/iae.0b013e3181a0848b
Abstract
To analyze the scan characteristics associated with poor-quality Stratus optical coherence tomograms submitted to a reading center for multicenter clinical trials. Data from evaluation of 6,741 fast macular thickness map reports from trials involving age-related macular degeneration (AMD), diabetic macular edema, and retinal vein occlusion were analyzed. Optical coherence tomograms with an erroneous centerpoint thickness needing manual remeasurement (MR) were categorized as being of poor quality. The frequency of MR and the artifacts associated were analyzed by disease type, underlying retinal morphology, and severity of retinal thickening. MR was performed in 2,027 (30%) optical coherence tomograms. AMD had the highest frequency of MR (54.9%), followed by retinal vein occlusion (23.9%) and diabetic macular edema (16.3%). Boundary line errors were the most common artifact across all disease types (61.3% of scans requiring MR) and increased with increasing retinal thickness. Decentration artifact was seen in 15.4% of scans requiring MR. The median absolute difference between machine and manually measured centerpoint thickness assessed in a subset of 84 scans was 75.5 microm. Artifacts causing erroneous reported centerpoint thickness are common. Identifying clues that indicate suboptimal quality of optical coherence tomography (OCT) images are important to avoid erroneous interpretation of OCT data in clinical trials.Keywords
This publication has 17 references indexed in Scilit:
- A Phase II Randomized Clinical Trial of Intravitreal Bevacizumab for Diabetic Macular EdemaOphthalmology, 2007
- Angiographic and Optical Coherence Tomographic Results of the MARINA Study of Ranibizumab in Neovascular Age-Related Macular DegenerationOphthalmology, 2007
- Randomized Trial of Peribulbar Triamcinolone Acetonide with and without Focal Photocoagulation for Mild Diabetic Macular Edema: A Pilot StudyOphthalmology, 2007
- An Optical Coherence Tomography-Guided, Variable Dosing Regimen with Intravitreal Ranibizumab (Lucentis) for Neovascular Age-related Macular DegenerationAmerican Journal of Ophthalmology, 2007
- Primary Intravitreal Bevacizumab (Avastin) for Diabetic Macular EdemaOphthalmology, 2007
- INTRAVITREAL BEVACIZUMAB (AVASTIN) TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATIONRetina, 2007
- Diurnal Variation in Retinal Thickening Measurement by Optical Coherence Tomography in Center-Involved Diabetic Macular EdemaAmerican Journal of Ophthalmology, 2006
- Evaluation of image artifact produced by optical coherence tomography of retinal pathologyAmerican Journal of Ophthalmology, 2005
- Optical coherence tomography to detect and manage retinal disease and glaucomaAmerican Journal of Ophthalmology, 2004
- Clinical applications of optical coherence tomographyCurrent Opinion in Opthalmology, 1999