Photosensitiser—antibody conjugates for photodynamic therapy
- 1 May 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC
- Vol. 10 (5), 721-750
- https://doi.org/10.1039/c0pp00266f
Abstract
Research into targeting of photodynamic sensitisers to specific biological tissue has been an area of increasing interest over the last twenty years. A significant number of these investigations have involved the use of antibodies or antibody fragments, and the field of photosensitiser bioconjugation is now an established area in its own right. This review seeks to bring together the diverse range of methodology now available for the efficient attachment of photodynamic agents to antibodies. The chemistry involved to obtain the complementary functionality required, on both photosensitiser and antibody, for successful conjugation is also discussed.Keywords
This publication has 87 references indexed in Scilit:
- Design and synthesis of water-soluble bioconjugatable trans-AB-porphyrinsTetrahedron, 2008
- Site-directed photoproteolysis of 8-oxoguanine DNA glycosylase 1 (OGG1) by specific porphyrin-protein probe conjugates: A strategy to improve the effectiveness of photodynamic therapy for cancerJournal of Photochemistry and Photobiology B: Biology, 2007
- Development and characterization of novel photosensitizer : scFv conjugates for use in photodynamic therapy of cancerImmunology, 2007
- Bioconjugatable Porphyrins Bearing a Compact Swallowtail Motif for Water SolubilityBioconjugate Chemistry, 2006
- Photochemical Targeting of Epidermal Growth Factor Receptor: A Mechanistic StudyClinical Cancer Research, 2005
- Efficacy of different targeting agents in the photolysis of interleukin-2 receptor bearing cellsJournal of Photochemistry and Photobiology B: Biology, 2004
- Protein‐A‐mediated Targeting of Bacteriochlorophyll‐IgG to Staphylococcus aureus: A Model for Enhanced Site‐Specific PhotocytotoxicityPhotochemistry and Photobiology, 1997
- Control of fibroblast populated collagen lattice contraction by antibody targeted photolysis of fibroblastsLasers in Surgery and Medicine, 1997
- Targetted phototherapy with sensitizer-monoclonal antibody conjugate and lightSurgical Oncology, 1993
- Photodynamic therapy of squamous cell carcinoma. An evaluation of a new photosensitizing agent, benzoporphyrin derivative and new photoimmunoconjugateSurgical Oncology, 1993