Photochemical Targeting of Epidermal Growth Factor Receptor: A Mechanistic Study
Open Access
- 15 February 2005
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (4), 1658-1668
- https://doi.org/10.1158/1078-0432.ccr-04-1902
Abstract
Purpose: Photoimmunotherapy may allow target-specific photodynamic destruction of malignancies and may also potentiate anticancer antibody therapies. However, clinical use of either of the two modalities is limited for different reasons. Antibody therapies suffer from being primarily cytostatic and the need for prolonged administration with consequent side effects. In the case of photoimmunotherapy, a major impediment has been the absence of well-characterized photosensitizer immunoconjugates (PIC). In this investigation, we suggest a strategy to overcome these limitations and present the successful targeting of epidermal growth factor receptor (EGFR) using a well-characterized PIC.Keywords
This publication has 38 references indexed in Scilit:
- Targeting Cells That Overexpress the Epidermal Growth Factor Receptor with Polyethylene Glycolated BPD Verteporfin Photosensitizer Immunoconjugates¶Photochemistry and Photobiology, 2003
- Release of Cytochrome c, Bax Migration, Bid Cleavage, and Activation of Caspases 2, 3, 6, 7, 8, and 9 during Endothelial Cell ApoptosisThe American Journal of Pathology, 1999
- Augmentation of a humanized Anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225Oncogene, 1999
- Protein‐A‐mediated Targeting of Bacteriochlorophyll‐IgG to Staphylococcus aureus: A Model for Enhanced Site‐Specific PhotocytotoxicityPhotochemistry and Photobiology, 1997
- Epidermal Growth Factor Receptor Family and ChemosensitizationJNCI Journal of the National Cancer Institute, 1997
- Enhanced photodynamic killing of target cells by either monoclonal antibody or low density lipoprotein mediated delivery systemsJournal of Controlled Release, 1992
- Antibody‐Targeted Photolysis: In Vitro Immunological, Photophysical, and Cytotoxic Properties of Monoclonal Antibody‐Dextran‐Sn(IV) Chlorin e6 ImmunoconjugatesBiotechnology Progress, 1992
- Photodynamic Killing of Human Squamous Cell Carcinoma Cells Using a Monoclonal Antibody-Photosensitizer ConjugateJNCI Journal of the National Cancer Institute, 1991
- Multiple-Drug Resistance in Human CancerThe New England Journal of Medicine, 1987
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970