Obesity phenotypes: depot-differences in adipose tissue and their clinical implications
- 31 January 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity
- Vol. 23 (1), 3-14
- https://doi.org/10.1007/s40519-017-0467-9
Abstract
Obesity, defined as excess fat mass, increases risks for multiple chronic diseases, such as type 2 diabetes, cardiovascular disease, and several types of cancer. Beyond adiposity per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for obesity complications. Not only factors as genetics, environment, gender, and age account for the apparent compartmentalization of white adipose tissue (WAT) in the body. Indeed, the heterogeneity among different anatomical depots also appears to stem from their intrinsic diversity, including cellular developmental origin, proliferative capacity, glucose and lipid metabolism, insulin sensitivity, cytokine pattern, thermogenic ability, and vascularization. Under the obese condition, these depot-specific differences translate into specific WAT distribution patterns, giving rise to different cardiometabolic consequences. This review summarizes the clinical and mechanistic evidence for the depot-specific differences and the phenotypic characteristics of different WAT depots that link their depot-specific biology to obesity-specific complications.Funding Information
- Ministero della Salute (Project n. 45/RF-2013-02357791)
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