The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse
- 15 January 2007
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 21 (2), 143-147
- https://doi.org/10.1101/gad.414807
Abstract
Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1–4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype th49, directly demonstrating the role of Fgd2 as Distorter. Fgd2 identifies a second Rho G protein signaling pathway promoting TRD.Keywords
This publication has 20 references indexed in Scilit:
- The t complex–encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in miceNature Genetics, 2005
- GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsNature Reviews Molecular Cell Biology, 2005
- Transmission Ratio Distortion in MiceAnnual Review of Genetics, 2003
- Fibrous sheath of mammalian spermatozoaMicroscopy Research and Technique, 2003
- Isolation, Characterization, and Mapping of the Mouse and Human Fgd2 Genes, Faciogenital Dysplasia (FGD1; Aarskog Syndrome) Gene HomologuesGenomics, 1999
- Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPasesCurrent Biology, 1996
- ADP‐ribosylation of Rho proteins inhibits sperm motilityFEBS Letters, 1993
- Deletion of mouset-complex distorter-1 produces an effect like that of thet-form of the distorterGenetics Research, 1992
- Five of the nine genetically defined regions of mousethaplotypes are involved in transmission ratio distortionGenetics Research, 1987
- Beat frequency is bimodally distributed in spermatozoa from T/t12 miceJournal of Experimental Zoology, 1979