ADP‐ribosylation of Rho proteins inhibits sperm motility
- 8 November 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 334 (1), 32-36
- https://doi.org/10.1016/0014-5793(93)81674-o
Abstract
The highly homologous Rho proteins RhoA, RhoB and RhoC are low-molecular-mass GTP-binding proteins. They are selectively ADP-ribosylated by Clostridium botulinum ADP-ribosyltransferase C3 (C3 exoenzyme). The biological function of the Rho proteins is still unclear; there is evidence that they are involved in the regulation of the filamental network of cells. Here we report that C3 exoenzyme-like toxins ADP-ribosylate small GTP-binding proteins in bovine spermatozoa and inhibit sperm motility. These findings indicate that Rho proteins which reportedly regulate the microfilament system are basically involved in sperm motility.Keywords
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