Investigating the added value of biomarkers compared with self-reported smoking in predicting future e-cigarette use: Evidence from a longitudinal UK cohort study
Open Access
- 14 July 2020
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 15 (7), e0235629
- https://doi.org/10.1371/journal.pone.0235629
Abstract
Biomarkers can be used to assess smoking behaviour more accurately and objectively than self-report. This study assessed the association between cotinine (a biomarker of smoke exposure) and later e-cigarette use among a population who were unexposed to e-cigarettes in youth. Young people in the Avon Longitudinal Study of Parents and Children took part in the study. We observed associations between cotinine at 15 years (measured between 2006 and 2008 before the wide availability of e-cigarettes) and self-reported ever use of e-cigarettes at 22 (measured between 2014 and 2015 when e-cigarettes were widely available) using logistic regression. A range of potential confounders were adjusted for (age, sex, body mass index, alcohol use and passive smoke exposure). Additionally, we adjusted for the young people’s self-reported smoking status/history to explore potential misreporting and measurement error. In a sample of N = 1,194 young people, cotinine levels consistent with active smoking at 15 years were associated with increased odds of e-cigarette ever use at 22 years (Odds Ratio [OR] = 7.24, 95% CI 3.29 to 15.93) even when self-reported active smoking status at age 16 (OR = 3.14, 95% CI 1.32 to 7.48) and latent classes of smoking behaviour from 14 to 16 (OR = 2.70, 95% CI 0.98 to 7.44) were included in the model. Cotinine levels consistent with smoking in adolescence were strongly associated with increased odds of later e-cigarette use, even after adjusting for reported smoking behaviour at age 16 and smoking transitions from 14 to 16.Funding Information
- Medical Research Council (102215/2/13/2)
- Wellcome Trust (102215/2/13/2)
- Medical Research Council (MC_UU_00011/7, MM_UU_00011/5)
- Cancer Research UK (C18281/ A19169)
- Cancer Research UK (C57854/A22171)
- Wellcome Trust (092731)
- Medical Research Council (092731)
- University of Bristol (de Pass Vice Chancellor Research Fellowship)
This publication has 30 references indexed in Scilit:
- Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohortInternational Journal of Epidemiology, 2012
- Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and ChildrenInternational Journal of Epidemiology, 2012
- Characterizing Patterns of Smoking Initiation in Adolescence: Comparison of Methods for Dealing With Missing DataNicotine & Tobacco Research, 2011
- Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients*Critical Care Medicine, 2011
- Methods for Quantification of Exposure to Cigarette Smoking and Environmental Tobacco Smoke: Focus on Developmental ToxicologyTherapeutic Drug Monitoring, 2009
- Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics supportJournal of Biomedical Informatics, 2008
- Assessing smoking status in children, adolescents and adults: cotinine cut‐points revisitedAddiction, 2008
- Misclassification rates for current smokers misclassified as nonsmokers.American Journal of Public Health, 1998
- Error in smoking measures: effects of intervention on relations of cotinine and carbon monoxide to self-reported smoking. The Lung Health Study Research Group.American Journal of Public Health, 1993
- Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.American Journal of Public Health, 1988