Olanzapine induced reproductive toxicity in male rats
Open Access
- 26 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-11
- https://doi.org/10.1038/s41598-021-84235-4
Abstract
Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system. In the scope of this research, it was aimed to assess the reproductive toxic effects of OLZ by oral administration of 2.5, 5, or 10 mg/kg of it to male rats for 28 days. For this purpose, sperm concentration, motility and morphology, and DNA damage were determined, and histopathological examination of testis tissue was carried out in rats. Also, the levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone, which play roles in the regulation of reproductive functions, and the levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) which play roles in reproductive pathologies as oxidative stress biomarkers, were determined. According to the results, normal sperm morphology was decreased in 5 ve 10 mg/kg OLZ-administered groups, and pathological findings were evident in the testicular structure of the OLZ-administered group when compared with the control group. It was determined that serum LH, FSH, and testosterone levels were decreased in the OLZ-administered group. Also, decreases of GSH levels in testis tissue were determined and evaluated as the markers of the oxidative stress induced by OLZ in the testis. In conclusion, it was determined that reproductive toxic effects were induced in rats by OLZ administration. This pathology was accompanied by alterations of the hormone levels and testicular oxidative stress.Funding Information
- Anadolu University (1401S018)
This publication has 61 references indexed in Scilit:
- The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytesToxicology and Industrial Health, 2011
- Endocrine and testicular changes induced by olanzapine in adult Wistar ratsJournal of Applied Toxicology, 2011
- SpermBlue®: A new universal stain for human and animal sperm which is also amenable to automated sperm morphology analysisBiotechnic & Histochemistry, 2010
- Fragmentation of DNA in morphologically normal human spermatozoaFertility and Sterility, 2009
- The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913)BMC Psychiatry, 2008
- Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in ratsNeuroscience, 2008
- Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?Toxicologic Pathology, 2004
- Superoxide dismutase activities of spermatozoa and seminal plasma are not correlated with male infertilityJournal of Clinical Laboratory Analysis, 2002
- Pathogenesis of Male Reproductive ToxicityToxicologic Pathology, 2001
- Dose dependent effects of inhaled ethylene oxide on spermatogenesis in rats.Occupational and Environmental Medicine, 1991