The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes
- 21 September 2011
- journal article
- Published by SAGE Publications in Toxicology and Industrial Health
- Vol. 28 (4), 327-333
- https://doi.org/10.1177/0748233711410919
Abstract
Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0–400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values ( p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.Keywords
This publication has 44 references indexed in Scilit:
- Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychoticsNeuroscience Letters, 2010
- The genotoxic and oxidative damage potential of olanzapine in vitroToxicology and Industrial Health, 2010
- Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC–MSJournal of Pharmaceutical and Biomedical Analysis, 2009
- A systematic review of cardiovascular effects after atypical antipsychotic medication overdoseThe American Journal of Emergency Medicine, 2009
- Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylationProceedings of the National Academy of Sciences of the United States of America, 2008
- Differential Effects of Various Typical and Atypical Antipsychotics on Plasma Glucose and Insulin Levels in the Mouse: Evidence for the Involvement of Sympathetic RegulationSchizophrenia Bulletin, 2008
- Clinical Pharmacokinetics of Atypical AntipsychoticsClinical Pharmacokinetics, 2007
- Age-related changes of antioxidant enzyme activities, glutathione status and lipid peroxidation in rat erythrocytes after heat stressLife Sciences, 2004
- Minimizing Cancer Risk Using Molecular Techniques: a ReviewToxicology and Industrial Health, 1997
- Sister chromatid exchanges induced by DNA demethylating agents persist through several cell cycles in mammalian cellsCarcinogenesis: Integrative Cancer Research, 1987