Endocrine and testicular changes induced by olanzapine in adult Wistar rats
- 21 July 2011
- journal article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 33 (1), 24-31
- https://doi.org/10.1002/jat.1702
Abstract
Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen‐dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis. Copyright © 2011 John Wiley & Sons, Ltd.Keywords
This publication has 24 references indexed in Scilit:
- Olanzapine affects locomotor activity and meal size in male ratsPharmacology Biochemistry and Behavior, 2010
- Lactational exposure to atypical antipsychotic drugs disrupts the pituitary-testicular axis in mice neonates during post-natal developmentJournal of Psychopharmacology, 2010
- Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in ratsNeuroscience, 2008
- Common and specific effects of the two major forms of prolactin in the rat testisAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Novel identification of peripheral dopaminergic D2 receptor in male germ cellsJournal of Cellular Biochemistry, 2006
- Estados hiperprolactinêmicos: inter-relações com o psiquismoArchives of Clinical Psychiatry (São Paulo), 2006
- Schizophrenia care and the Dutch community pharmacy: the unmet needsInternational Journal of Pharmacy Practice, 2003
- Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in humanPharmacology Biochemistry and Behavior, 2003
- Treatment of Weight Gain with Fluoxetine in Olanzapine-Treated Schizophrenic OutpatientsNeuropsychopharmacology, 2002
- Regulation of Epididymal Epithelial Cell Functions1Biology of Reproduction, 1995