Towards understanding the antagonistic activity of phytic acid against common foodborne bacterial pathogens using a general linear model
Open Access
- 17 April 2020
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 15 (4), e0231397
- https://doi.org/10.1371/journal.pone.0231397
Abstract
The increasing challenge of antibiotic resistance requires not only the discovery of new antibiotics, but also the development of new alternative approaches. Therefore, in the present study, we investigated for the first time the antibacterial potential of phytic acid (myo-inositol hexakisphosphate, IP6), a natural molecule that is ‘generally recognized as safe’ (FDA classification), against the proliferation of common foodborne bacterial pathogens such as Listeria monocytogenes, Staphylococcus aureus and Salmonella Typhimurium. Interestingly, compared to citric acid, IP6 was found to exhibit significantly greater inhibitory activity (PL. monocytogenes, S. aureus and S. Typhimurium. Overall, the models were able to accurately predict the growth of L. monocytogenes, S. aureus, and S. Typhimuriumin Polymyxin acriflavine lithium chloride ceftazidime aesculin mannitol (PALCAM), Chapman broth, and xylose lysine xeoxycholate (XLD) broth, respectively. Remarkably, the early logarithmic growth phase of S. Typhimurium showed a rapid and severe decrease in a period of less than one hour, illustrating the bactericidal effect of IP6. These results suggest that IP6 is an efficient antibacterial agent and can be used to control the proliferation of foodborne pathogens. It has promising potential for environmentally friendly applications in the food industry, such as for food preservation, food safety, and for prolonging shelf life.Keywords
This publication has 48 references indexed in Scilit:
- Incidence of Staphylococcus aureus and Analysis of Associated Bacterial Communities on Food Industry SurfacesApplied and Environmental Microbiology, 2012
- Determination of bactericidal efficacy of essential oil extracted from orange peel on the food contact surfacesFood Control, 2010
- Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in ratsExperimental and Toxicologic Pathology, 2010
- Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysisMolecular Nutrition & Food Research, 2009
- Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's diseaseToxicology, 2008
- Antimicrobial and antioxidant properties of the essential oils and methanol extract from Mentha longifolia L. ssp. longifoliaFood Chemistry, 2007
- Screening methods to determine antibacterial activity of natural productsBrazilian Journal of Microbiology, 2007
- Phytate (Myo-inositol hexakisphosphate) inhibits cardiovascular calcifications in ratsFrontiers in Bioscience-Landmark, 2006
- Methods to Reduce/Eliminate Pathogens from Fresh and Fresh‐Cut ProduceComprehensive Reviews in Food Science and Food Safety, 2003
- IP6: A novel anti-cancer agentLife Sciences, 1997