(Oligo)metastasis as a Spectrum of Disease
- 15 January 2021
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (10), 2577-2583
- https://doi.org/10.1158/0008-5472.can-20-3337
Abstract
Cancer metastasis is the leading cause of cancer-related mortality, and most patients with metastases from solid tumors have historically been considered incurable. Here we discuss the evolution of our understanding of the oligometastatic state with an emphasis on the view that cancer metastasis represents a spectrum of disease. We highlight several recently published prospective clinical trials demonstrating improvements in cancer-specific outcomes with the utilization of metastasis-directed local therapies. We discuss biological aspects of oligometastases including genetic, epigenetic, and immune determinants of the metastatic spectrum. Finally, we propose future considerations regarding clinical trial design for patients with oligometastatic disease.Keywords
Funding Information
- Ludwig Cancer Research Foundation (N/A (internal grant))
- Foglia Family Foundation (N/A (internal grant))
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