The Role of Maintenance Therapy in Disseminated Testicular Cancer
- 24 September 1981
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 305 (13), 727-731
- https://doi.org/10.1056/nejm198109243051303
Abstract
We conducted a prospective study of the value of maintenance therapy in disseminated testicular cancer after chemotherapy-induced complete remission or chemotherapy cytoreduction followed by surgical resection of residual teratoma. A group of 171 patients were randomized to treatment consisting of cisplatin, vinblastine, and bleomycin, or these drugs plus doxorubicin. There was no apparent difference between these two induction regimens. Complete remission was achieved in 113 patients (66 per cent), and 19 (11 per cent) were free of disease by surgical resection of residual tumor. Of the 171 who started, 113 were eligible to receive either maintenance doses of vinblastine (58 patients) or no further therapy (55 patients) after remission-induction therapy. There was a 9 per cent relapse rate during maintenance with vinblastine and a 7 per cent relapse rate with no maintenance therapy; the overall relapse rate was 8 per cent (nine of 113). Our data indicate that maintenance therapy is unnecessary in disseminated testicular cancer. (N Engl J Med. 1981; 305:727–31.)Keywords
This publication has 10 references indexed in Scilit:
- VP-16–213 salvage therapy for refractory germinal neoplasmsCancer, 1980
- Aggressive Surgical Management of Testicular Carcinoma Metastatic to Lungs and MediastinumThe Annals of Thoracic Surgery, 1980
- Chemotherapy of disseminated testicular cancer a random prospective studyCancer, 1980
- Vinblastine, bleomycin and cis-diamminedichloroplatinum in the treatment of advanced testicular carcinoma: Possible importance of longer induction and shorter maintenance schedulesAmerican Journal Of Medicine, 1980
- The Management of Disseminated Testicular CancerBritish Journal of Urology, 1980
- COMBINATION CHEMOTHERAPY WITH CIS-DIAMMINE-DICHLORO-PLATINUM, VINBLASTINE, AND BLEOMYCIN IN ADVANCED TESTICULAR NON-SEMINOMAThe Lancet, 1979
- Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular CancerAnnals of Internal Medicine, 1977
- Mithramycin therapy in advanced testicular neoplasmsCancer, 1970
- A generalized Wilcoxon test for comparing arbitrarily singly-censored samplesBiometrika, 1965
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958