COVID-19 mRNA vaccine in pregnancy and newborn passive immunization: a case report

Abstract

Aim: Evaluating the newborn passive immunization after maternal vaccination against SARS-COV-2. Case presentation: We present the case of a pregnant woman, with no prior history of COVID-19 infection, who got her second dose of mRNA vaccine against SARS-COV-2, 3 days before the start of her spontaneous labor. She was delivered by cesarean section after dynamical dystocia. Placental cord blood was retrieved immediately and sent to evaluate the titers of COVID-19 antibodies. Vaccine-generated antibodies were present in the umbilical cord with IgG spike >100 AU/ml. Conclusion: By reviewing the literature, vaccination seems to give hope about the potential protective effect of the maternal vaccination on her baby. Thus, pregnant women deserve a priority in the COVID-19 vaccination program. Lay Counseling pregnant patients about COVID-19 vaccine safety for her and her fetus is a common issue facing obstetricians. The WHO does not recommend the vaccination for pregnant women except for patients considered with unavoidable risk of high exposure. We present the case of a pregnant woman, with no prior history of COVID-19, who got her second dose of mRNA vaccine against SARS-COV-2, 3 days before the start of her spontaneous labor. Vaccine-generated antibodies were present in the umbilical cord. In conclusion, vaccination seems to give hope about the potential protective effect of the maternal vaccination on her baby.