Line‐field confocal optical coherence tomography of basal cell carcinoma: a descriptive study
Top Cited Papers
- 7 December 2020
- journal article
- research article
- Published by Wiley in Journal of the European Academy of Dermatology and Venereology
- Vol. 35 (5), 1099-1110
- https://doi.org/10.1111/jdv.17078
Abstract
Background Early diagnosis and subtype classification of basal cell carcinoma (BCC) are crucial to reduce morbidity and optimise treatment. Good accuracy in differentiating BCC from clinical imitators has been achieved with existing diagnostic strategies but lower performance in discriminating BCC subtypes. Line‐field confocal optical coherence tomography (LC‐OCT) is a new technology able to combine the technical advantages of reflectance confocal microscopy and OCT. Objectives To identify and describe LC‐OCT criteria associated with BCC and explore their association with BCC subtypes. Methods BCCs were imaged with a handheld LC‐OCT device before surgical excision. LC‐OCT images were retrospectively evaluated by three observers for presence/absence of criteria for BCC. Multivariate logistic regression models were used to find independent predictors of BCC subtypes. Results Eighty‐nine histopathologically proven BCCs were included, of which 66 (74.2%) pure subtypes [superficial BCC (sBCC): 19/66 (28.8%); nodular BCC (nBCC): 31/66 (47.0%); infiltrative BCC (iBCC): 16/66 (24.2%)]. Lobules, blood vessels, and small bright cells within epidermis/lobules were the most frequent criteria for BCC. LC‐OCT criteria independently associated with sBCC were: presence of hemispheric lobules, absence of lobule separation from the epidermis, absence of stretching of the stroma; with nBCC: presence of macrolobules, absence of lobule connection to the epidermis; with iBCC: presence of branched lobules. Conclusions This was the first study describing the characteristics of BCC under LC‐OCT examination. We proposed morphologic criteria, which could be potentially useful for diagnosis and subtype classification of BCC, as well as for its therapeutic management. Future studies are needed to assess these hypotheses.Keywords
This publication has 57 references indexed in Scilit:
- Histological correlates of optical coherence tomography in non‐melanoma skin cancerSkin Research and Technology, 2012
- Morphology of basal cell carcinoma in high definition optical coherence tomography: en‐face and slice imaging mode, and comparison with histologyJournal of the European Academy of Dermatology and Venereology, 2012
- How histological features of basal cell carcinomas influence image quality in optical coherence tomographyJournal of Biophotonics, 2011
- Peritumoral clefting in basal cell carcinoma: correlation of in vivo reflectance confocal microscopy and routine histologyJournal of Cutaneous Pathology, 2010
- Estudo quantitativo das células de Langerhans em carcinomas basocelulares com maior e menor potencial de agressividade localAnais Brasileiros de Dermatologia, 2010
- Optical coherence tomography for the characterization of basal cell carcinoma in vivo: A pilot studyJournal of the American Academy of Dermatology, 2006
- Reflectance confocal microscopy of pigmented basal cell carcinomaJournal of the American Academy of Dermatology, 2006
- Real-time, in vivo confocal reflectance microscopy of basal cell carcinomaJournal of the American Academy of Dermatology, 2002
- Melanoma or pigmented basal cell carcinoma: a clinical‐pathologic correlation with dermoscopy, in vivo confocal scanning laser microscopy, and routine histologySkin Research and Technology, 2002
- Why classify basal cell carcinomas?Histopathology, 1998